What do the Pope, a suitcase full of baking powder, four naive friends and the organ mafia have to do with each other? They are all part of a macabre and grotesque story with a lot of heart and a good dose of black humor. Sandpit friends Rico, Sigi, Dave and Glotze dream of cashing in big time. However, they hadn't planned on falling into the clutches of a drug baron and shady organ dealer. Their only chance is to play along with their adversaries - at least until they realize which heart really matters...

Mit Herz und Handschellen is a German television series.

The physician Dr. Katrin Herz needs support in her practice in Tangermünde. She finds it in the young Dr. Holly Sass. The Berlin city plant only agrees to the job on the Elbe in order to follow a promising lead to her missing mother. Dr. Katrin Herz puts her in touch with the previous practice owner, who probably knew Holly's mother as a patient.

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Manuel is the right-hand man of drug lord Renato Calvi. After Manuel witnesses his boss brutally punishing a man who apparently betrayed him to the police, he decides to break away from Renato and go into business for himself. Renato is not happy about this and now wants to involve Manuel's younger brother TS in his business. But what no one suspects is that TS is working closely with the police!

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When Isa provokes the Nazis with a satirical song at her graduation party, she is denied her degree despite passing her exams. She has to give up her plan to become a teacher and, against her mother Petra's wishes, manages to perform in a political cabaret. She enjoys stage success as a singer with an accordion and falls in love with the pianist Laurenz. During the Second World War, Isa's family gets caught up in the wheels of political power and is torn apart - until, after much turbulence, the Vermehrens regain their old cohesion and accompany Isa together as she enters a convent in Bonn.

Valerie Cornelis has inherited a house in Bruges. The only thing Valerie associates with this city is chocolate. And Valerie hates chocolate! But in Bruges, she reflects anew. She has actually set out to sell the unknown legacy of her deceased mother as soon as possible to eliminate the leftover mountain of debt. But hardly arrived in Bruges, the most impossible things happen. The planned short trip to Bruges will be a journey into a world she never dared dream of and in which she finds happiness.

Until now, Carlo thought he was living a quiet, manageable life. And he seemed content with his "small world". But somehow, things have not been running smoothly in Carlo's life for a few weeks now. At home, problems are emerging with his son Hendrik and wife Jutta. His now somewhat outdated garage, which he has been running for 30 years, is hardly generating any orders, and even his tortoise Adenauer is giving him grief because she has stopped eating. And now? Carlo has no intention of letting his long-serving employees Becker, Roger and Köll go, because they are more than just his employees. They are his best friends, without whom Carlo's life would really no longer be possible.